A decrease in the functioning of your kidneys may develop suddenly or over a long duration of time and may cause symptoms such as changes in urination, swelling in your lower body and overall fatigue. Low functioning of your kidneys can happen for many reasons, including damage to the kidneys and other internal organs. According to the Mayo Clinic and the National Library of Medicine, low kidney function may be caused by inflammation, infections and poisoning.
Inflammation
Inflammation within your kidneys can be caused by allergic reactions to antibiotics, immune system disorders such as lupus or chronic conditions such as liver disease.
Infections
Bacterial infections with Escherichia coli or strep throat or infections with viral hepatitis may cause low kidney functions that can develop into kidney failure if left untreated.
Toxins
An overdose of pain relievers such as acetaminophen or aspirin, heavy alcohol consumption, drug use and exposure to manufacturing or industrial chemicals may be the cause of low function in your kidneys.
Artery Disorders
Disorders of the arteries inside of your kidneys or that lead to your kidneys may cause you to have low kidney functions as a result of poor blood flow.
Cardiac Disorders
Infections in or around your heart, low blood pressure, heart attack or heart failure may cause circulation problems throughout your body and cause low kidney function.
Obstructions
Low kidney functions may result from obstructions in your excretory system, such as kidney and bladder stones, enlarged prostate or tumors of the bladder or kidneys.
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