Leukotriene is one example of an eicosanoid. "Eicosanoids" is a collective term for prostaglandin and related compounds. They are referred to as the "local hormones" of the body. They have various roles in the regulation of the immune system.
Classification
Leukotrienes are classified into two types: cysteinyl and non-cysteinyl. Cysteinyl leukotrienes include C4, D4 and E4, while the non-cysteinyl leukotriene is B4.
Synthesis
The synthesis of leukotrienes follows a linear pathway initially catalyzed by the action of a specific enzyme, lipoxygenase. The arachidonic acid serves as the raw material and the leukocytes as the primary synthesizer.
Significance
Leukotrienes play an important role in the immune defense of the body. They mediate inflammation in atherosclerosis and aid in blood clotting.
Diseases
Diseases such as asthma and allergy are brought about by the overproduction of leukotrienes, particularly cysteinyl leukotrienes. On the other hand, the non-cysteinyl leukotriene B4 is likely to cause chronic inflammation.
Treatment
The asthma medication, Zyflo, works by inhibiting the synthesis of leukotriene. Medications like Singulair and Accolate interfere with leukotriene-receptor interactions.
Tags: body They, non-cysteinyl leukotriene