An exostosis is a bony growth that arises from the surface of a bone that is covered in cartilage. Exotoses are the most common bone tumor in children but the true prevalence of solitary exotoses is not known because they are frequently asymptomatic and never diagnosed. Hereditary multiple exotoses is characterized by many exotoses throughout the skeleton. It can cause severe symptoms. Here's prevent exostoses.
Instructions
1. Examine the means of inheritance for hereditary multiple exotoses. It is an autosomal dominant trait; anyone who is a carrier also will have the disorder. An hereditary multiple exotoses carrier and a normal person have a 50 percent chance of having a child with hereditary multiple exotoses.
2. Get genetic counseling to assess your risk of having a child with hereditary multiple exotoses. There are at least three different genes (called EXT genes) that cause some type of hereditary multiple exotoses.
3. Test for the EXT1 gene on chromosome 8 in the q23 and q24 regions. These regions have the most common mutation that causes hereditary multiple exotoses and are known to control tumor suppression. The EXT2 gene is on chromosome 11 in regions p11 and p12 with characteristics similar to EXT1.
4. Determine the presence of the EXT3 gene on the p arm of chromosome arm 19. This gene is involved in hereditary multiple exotoses much less frequently than the other two.
5. Check for the presence of other genetic disorders that have been linked to hereditary multiple exotoses but are more easily diagnosed. These include DEFECT 11 syndrome, Langer-Giedon syndrome and trichorhinophalangeal syndrome type II.
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